2021 Apertura Standings
| Pos | Club | P | W | D | L | F | A | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  America | 17 | 10 | 5 | 2 | 21 | 10 | 11 | 35 |
| 2 |  Atlas | 17 | 8 | 5 | 4 | 21 | 10 | 11 | 29 |
| 3 |  Club León | 17 | 8 | 5 | 4 | 20 | 14 | 6 | 29 |
| 4 |  U.A.N.L Tigres | 17 | 7 | 7 | 3 | 26 | 14 | 12 | 28 |
| 5 |  Santos | 17 | 5 | 9 | 3 | 23 | 16 | 7 | 24 |
| 6 |  Toluca | 17 | 6 | 6 | 5 | 22 | 22 | 0 | 24 |
| 7 |  Puebla | 17 | 6 | 6 | 5 | 16 | 16 | 0 | 24 |
| 8 |  Cruz Azul | 17 | 5 | 8 | 4 | 21 | 17 | 4 | 23 |
| 9 |  Monterrey | 17 | 5 | 7 | 5 | 19 | 16 | 3 | 22 |
| 10 |  Chivas | 17 | 5 | 7 | 5 | 13 | 13 | 0 | 22 |
| 11 |  Pumas UNAM | 17 | 5 | 6 | 6 | 17 | 23 | -6 | 21 |
| 12 |  San Luis | 17 | 4 | 8 | 5 | 19 | 23 | -4 | 20 |
| 13 |  Mazatlán F.C. | 17 | 5 | 5 | 7 | 18 | 24 | -6 | 20 |
| 14 |  Necaxa | 17 | 6 | 2 | 9 | 16 | 22 | -6 | 20 |
| 15 |  Tuzos | 17 | 4 | 6 | 7 | 19 | 21 | -2 | 18 |
| 16 |  FC Juarez | 17 | 4 | 4 | 9 | 14 | 25 | -11 | 16 |
| 17 |  Querétaro | 17 | 3 | 6 | 8 | 11 | 19 | -8 | 15 |
| 18 |  Tijuana | 17 | 3 | 6 | 8 | 16 | 27 | -11 | 15 |